The results of that massive cross-analysis also appear in today's study. Intriguing associations were documented involving 94 conditions. After devoting decades of research to hunting down the causes of lupus, Harley says this study represents the most important discovery of his career. This one is more important than all of the rest put together. It is a capstone to a career in medical research," he says.
Detecting and tracking the activities of these transcription factors took years of work involving dozens of laboratory and computational experts. The project required gathering massive sets of genetic data, then analyzing every genetic change affecting the activity of the virus. Use this form if you have come across a typo, inaccuracy or would like to send an edit request for the content on this page.
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By using our site, you acknowledge that you have read and understand our Privacy Policy and Terms of Use. Home Genetics. April 16, This electron microscopic image of two Epstein Barr Virus virions viral particles shows round capsids—protein-encased genetic material—loosely surrounded by the membrane envelope.
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A team of researchers led by Dr. John B. The results were published online on April 16, , in Nature Genetics. Past studies had identified more than 50 genetic regions associated with lupus. Most are thought to be involved in gene regulation. The team found that a viral protein called EBNA2 was associated with nearly half of the genetic regions associated with the risk for lupus. Mono caused by EBV is most common among teens and adults.
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